Poor aqueous solubility of drugs is often a challenging task for formulators in the industry as the solubility is an essential factor for drug effectiveness, independent of the route of administration.. Conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly soluble simultaneously in aqueous and in non-aqueous media. Nanosuspension formulation can be used to enhance the solubility as well as the bioavailability of poorly soluble drugs. Nanosuspension is a biphasic system consisting of pure drug particle dispersed in an aqueous vehicle in which diameter of the suspended particle is less than 1000nm in size, with an average particle size ranging between 200 and 600 nm. These are simple to prepare and are more advantageous than other approaches. Techniques such as wet milling, high-pressure homogenization, emulsification-solvent evaporation and super critical fluid have been used in the preparation of nanosuspensions. It has the advantage of delivery by various routes, including oral, parenteral, pulmonary and ocular routes. The present review consist of the current methods used to prepare nanosuspensions, their application, advantages and their application in drug delivery.
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